Forschung Radio-Onkologie

Prof. Dr. Stephan Bodis besitzt einen Lehrauftrag für Molekulare Strahlenbiologie an der Medizinischen Fakulät der Universität Zürich.

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Professur für Molekulare Strahlenbiologie Uni Zürich

Standardbehandlung bei muskel-invasiven Blasenkarzinomen ist eine radikale Zystektomie. Falls ein Patient aus medizinischen Gründen nicht operabel ist oder bei Patientenwunsch nach funktioneller Organerhaltung, kann eine trimodale radikale Thermo-/Radio-/Chemotherapie nach unserem Phase-II- Protokoll interdisziplinär diskutiert und empfohlen werden (s. Flowchart).

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Flowchart muskel-invasive Blasenkarzinome

Bei primär inoperablem, lokal fortgeschrittenem Pankreaskarzinom können die Patienten nach interdisziplinärer Besprechung und primärer Chemotherapie (4 Zyklen FOLFIRINOX)  in die zweiarmige Phase-II-HEATPAC-Studie randomisiert werden: Radiochemotherapie (Kontrollarm: Bestrahlung mit 56 Gy in 28 Fraktionen begleitet von Gemcitabin wöchentlich) vs. Radiochemotherapie (wie oben) + Tiefenhyperthermie wöchentlich (Kontrollarm).

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Flowchart lokal fortgeschrittenes Pankreaskarzinom

Lokal fortgeschrittene oder rezidivierende Weichteilsarkome, welche aus medizinischen Gründen oder nicht primär funktionserhaltend operiert werden können, oder bei Patienten, welche eine Operation ablehnen, kann nach interdisziplinärer Besprechung am Sarkomboard eine präoperative oder definitive Behandlung mit Protonen-Bestrahlung kombiniert mit regionärer Tiefenhyperthermie im Rahmen der Phase-II-HYPROSAR-Studie angeboten werden (s. Flowchart).

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Flowchart Weichteilsarkome

• Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?
• Stellenwert der regionären Hyperthermie in der Krebstherapie
• Hyperthermie in der Krebsbehandlung
• Abstracts 2016
• Abstracts 2017

Publications

Datta, N. R., Rogers S, Puric E, Ordóñez, SG, Bodis S
Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis
Int J Hyperthermia 2015, http://dx.doi.org/10.3109/02656736.2015.1099746 (in press)

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Datta, N. R., Ordóñez, SG, Gaipl US, Paulides MM, Creeze H, Gellermann J, Marder D, Puric E, Bodis S
Local hyperthermia combined with radiotherapy and /-or chemotherapy: Recent advances and promises for the future
Cancer Treat Rev 2015 Nov;41(9):742-53.

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Datta, N.R., Samiei M, Bodis S
Are new radiation therapy facilities economically viable in low-and middle-income countries?
Int J Radiat Oncol Biol Phys 2015;93:229-40,2015.

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Datta, N.R., Grobholz R, Puric E, Bode B, Khan S, Lomax N. Gaipl US, Fuchs B, Bodis S
Enhanced tumour regression in a patient of liposarcoma treated with radiotherapy and hyperthermia: Evidence for dynamic immunomodulation by hyperthermia
Int J Hyperthermia 2015; 31: 574-577.

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Datta, N.R., Puric E., Heüberger, J., Marder D., Lomax, D., Timm, O., Meminger, P., Bodis, S
Hyperthermia and re-irradiation for loco- regional recurrences in pre-irradiated breast cancers: A single institutional experience
Swiss Med Weekly, 2015, 145:w14133.

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Datta, N.R., Singh, S., Kumar, P., Gupta, D
HPV confers radiosensitivity in cancer cervix: A hypothesis towards a possible restoration of apoptotic pathways based on clinical outcomes
Future Oncol, 2015;11: 1363-71.

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Datta, N.R., Schneider R, Puric E, Fuchs B, Studer G, Weber D C, Bodis S
“HYPROSAR”: A phase I7II pilot study of proton radiotherapy and hyperthermia in primary or recurrent unresev^ctable adult soft tissue sarcoma (ClinicalTrials.gov NCT01904565)
Schweizer Krebsbulletin 2015; 4: 338.

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Datta, N.R., Heuser M, Samiei M, Shah R, Lutters G, Bodis S
Teleradiotherapy network: Applications and feasibility for providing cost effective comprehensive radiotherapy care in low-and middle-income group countries for cancer patients
Telemed and e Health, 2015; 21:523-532.

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Datta, N.R. Ordonez SG, Bodis S
Radiation therapy for non-small cell cancer lung: Current concepts
InfoOnkologie & Heamotolgie 2015: 3; 6-12.

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Datta, N.R., Puric E, Schneider R, Weber D, Susanne R, Bodis S
Could hyperthermia with proton mimic carbon ion therapy? Exploring a thermo-radiobiological rationale
Int J Hyperthermia 2014; 30(7)524-530.

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Datta, N.R., Samiei M, Bodis S
In reply to Sharma et al.
Int J Radiat Oncol Biol Phys, 2014; 90: 971-972.

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Datta, N.R., Samiei M, Bodis S
Radiotherapy infrastructure and human resources in Europe – present status and its implications for 2020
Europ J Cancer, 50: 2735-2743, 2014.

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Srivastava A, Datta NR
Brachytherapy in cancer Cervix. Time to move beyond “point A”?
World J Clin Oncol 2014; 5(4): 764-774.

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Datta N.R., Samiei M, Bodis S
Radiation therapy infrastructure and human resources in low- and middle-income countries: present status and projections for 2020
Int J Radiat Oncol Biol Phys, 89; 448-457, 2014. 

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Datta N.R., Puric E, Schneider R, Fuchs B, Bodis S, Weber D
HYPROSAR: Hyperthermia and Proton Radiotherapy in Soft Tissue Sarcoma
Leading Opinions in Oncology 2014; 2: 158-160.

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Datta N.R., Puric E, Bodis S
2014 Hyperthermia: its role in soft tissue sarcomas and recurrent breast carcinomas
Info@Onkologie, 2014, 4;34-36.

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Datta N.R., Heuser M, Samiei M, Shah R, Lutters, Bodis S
Tele-radiotherapy network for low- and middle –income group countries for providing cost effective comprehensive radiotherapy care for cancer patients
In: Al-Shanableh T, Dabaj F, editors. Proceedings of the 2nd international conference on e-health and telemedicine and international course on tele-pathology systems and applications, Istanbul, Turkey. ICEHTM; 2014, p121-30.
Datta NR, Bodis S. Personalized radiation oncology: From “4 lines” to “4 dimensions” Schweizer Krebsbulletin  2014: 34 (1);20

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Abstracts

Datta NR, Puric E, Klingbiel D, Bodis. S
A systematic review and meta-analysis for re-irradiation with hyperthermia for loco-regional recurrent breast cancers
Strahlenther Oncol 2005;191:900-901.

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Datta N.R., Bodis S
Radiotherapy infrastructure and human resources in Switzerland: Present status and projections for 2020
Strahlenther Oncol 2005;191:901.

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Datta NR, Puric E, Klingbiel D, Bodis. S
A systematic review and meta-analysis for re-irradiation with hyperthermia for loco-regional recurrent breast cancers
ESHO, 2015, Zurich, p74.

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Chaachouay H, Pruschy M, Datta NR, Bodis S, Roher Bley C
Hyperthermia response and radioresistance of canine tumour cells invitro
ESHO, 2015, Zurich, p78.

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Dressel S, Chaachouay H, Bodis S, Datta NR, Roher Bley C
Serum levels of heat shock protein 70 in dogs and cats with cancer
ESHO, 2015, Zurich, p36.

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Puric E, Meister A, Eberle E, Datta NR, Marder D, Timm O, Heuberger J, Bauer S, Baumgartner M, Bodis S
Deep hyperthermia in treatment of muscle invasive bladder cancer for elkderly patients: A single centre’s first experience
ESHO, 2015, Zurich, p68.

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Datta NR, Puric E, Schneider R, Weber D, Marder D, Timm O, Studer G, Meister A, Fuch B, Bodis S
Hyperthermia and proton irradiation in unresectable soft tissue sarcoma: First result from “HYPROSAR” study
ESHO, 2015, Zurich, p22.

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Datta NR, Puric E, Klingbiel D, Bodis S
Re-irradiation with hyperthermia for locoregional recurrent breast cancer: a systematic review and meta-analysis
SASRO, Basel, 2015.

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Datta NR, Puric E, Klingbiel D, Bodis S
Re-irradiation with hyperthermia for locoregional recurrent breast cancer: a systematic review and meta-analysis
Radiother Oncol, 2015, 115, S333.

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Bodis S, Datta NR, Kuster N, Rohrer Bley C, Lutters G, Scheidegger S, Puric E
Hyperthermia and radiation therapy: potentials for synergy and future developments
Radiother Oncol, 2015, 115, S151.

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Datta NR, Puric E, Meister A, Lomax N, Marder D, Timm O, Spoerri P, Bodis S
Effectiveness of radiation and hyperthermia in elderly patients with bladder carcinoma: preliminary results from an ongoing study
SASRO, Lugano, March 2014, Strahlenther Oncol 2015, 191:95.

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Datta NR, Khan, S, Lutters G, Bodis S
Staff projections with increasing adaptations to high precisions radiotherapy planning at KSA
SASRO, Lugano, March 2014, Strahlenther Oncol 2015,191:96.

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Puric E. Datta NR, Heuberger J, Lomx N, Timm O, Marder D, Memminger P, Bodis S
Hyperthermia and re-irradiation for loco-regional recurrences in breast cancers
SASRO, Lugano, March 2014, Strahlenther Oncol 2015,191:83.

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Marder D,Brändli N, Lomax N, Lutters G, Datta NR, Timm O
Improved machine control in deep hyperthermia with a newly developed 3D E-field scanning phantom
SASRO, Lugano, March 2013, Strahlenther Oncol 2015,191:102.

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Datta, N. R., Srivastava, A. Rogers, S., Khan, S., Bodis, S
“Radiation therapy in the multimodality management of oesophageal cancer : where do we stand?  (Guest lecture)
15th Asian Oceanian Congress of Radiology, Sept 24- 28, 2014, Kobe, Japan 

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Datta N.R., Puric E, Schneider R, Fuchs B, Bodis S, Weber D.C
Thermoradiobiological basis of “HYPROSAR”: A clinical trial with hyperthermia and proton radiotherapy in unresectable soft tissue sarcoma
ESHO, Turino, 11-14 June 2014, Italy, Panminerva Medica, 56, p5-6, 2014

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Puric E, Datta N.R., Heuberger J, Lomax, N, Timm O, Marder D, Memminger P, Bodis S
Hyperthermia and re-irradiation for postirradiated locoregionally recurrent breast cancer: a single institutional experience
ESHO, Turino, 11-14 June 2014, Italy, Panminerva Medica, 56, p15-16, 2014.

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Marder D, Brandli N, Lomax N, Timm O, Lutters G, Datta N.R
First results with a new 3D E filed scanning phantom for quality assurance in deep hyperthermia systems
ESHO, Turino, 20-21 June 2014, Italy, Panminerva Medica, 56, p15-16, 2014.

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Scheidegger S, Bonmarin M, Timm O, Rhodes S, Datta, NR
Estimating radiosensitization based on re-oxygenation after hyperthermia by using dynamic models
ESHO, Turino, 11-14 June 2014, Italy, Panminerva Medica, 56, p24, 2014.

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Pestalozzi B, Datta N.R., Riesterer O, DeOliviere ML, et al.
Multimodality treatment approach for locally advanced pancreatic cancer (ongoing trial).
Annals Oncol, 25 (suppl 2): ii52 – i53, 2014.

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Datta, N.R., Samiei M, Bodis, S
Present and future status of radiation therapy in low-middle income countries:  an imminent global crisis
Radiother Oncol, 111, Suppl 1, 2014,223.

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Datta N.R, Puric E, Heubergerer J, Lomax N, Timm O, Marder D, Memminger P, Bodis S
Hyperthermia and re-irradtaion for effective treatment of locoregional recurrences in breast cancers
Radiother Oncol, 111, Suppl 1, 2014,477.

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Khuller P, Sinha S, Garg C, Datta N.R
Is IMRT superior to 3D CRT for postmastectomy irradiation ?  An in-silico comparative planning study
Radiother Oncol, 111, Suppl 1, 2014,620.

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Datta, N. R, Kahn S, Meister A, Puric E, Lutters G, Rabe E, Bodis S
Present and future radiation therapy infrastructure in Europe: A wake up call to cut the mustard?
Europ J Cancer, 49, Suppl 2, 2013, S 219.

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Datta, N.R, Puric E, Eberle B, Lomax N, SpoerriP, SeilerD, ZimmermannM, LehmannK, Bodis S
Variations in thermal parameters in hyperthermia of bladder cancers: A preliminary QA from an ongoing national trial
Radiother Oncol, 2013,106(Suppl), S274.

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Datta NR, Singh S, Kumar P, Gupta D, Bodis S
Does the quantum of local tumour HPV positivity in cervix cancers lead to a radiobiologically different tumour cell population?
Wolfsberg Meeting, June 2013

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Datta NR, Puric E, Lomax N, Scheidegger S, Marder D, Bodis S
Time - Temperature Area Under Curve (TT-AUC): A Proposal for a Novel Thermometric Parameter for Clinical Hyperthermia in Bladder Cancers
ESHO , Munich, June 2013

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Datta NR, Puric E, Geismar JH, Eberle B, Meister A, Lomax N,  Lomax T, Goitein G, Fuchs B, Studer G, Pruschy M, Bley CR, Kuster N, Caspar C, Spoerri P, Tschaler O,Mamot C, Weber D, Bodis S
Proposals for Future Clinical Trials in Hyperthermia
ESHO , Munich, June 2013

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Puric E, Datta NR, Eberle B, Lomax N, Spoerri P, van der Zee J, Bodis S
Deep hyperthermia along with chemoradiotherapy in bladder cancer: Initial experience in Aarau with 2 year follow-up
ESHO, Munich, June 2013

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Scheidegger S, Lomax N, Olaf T, Datta NR, Fuschlin RM, Bodis S
Characterization of hyperthermia with radiotherapy: temporal homogeneity and limitations of the CEM concept
ESHO, Munich, June 2013

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Datta NR, Puric E, Lomax N, .Marder D, Lutters G, Geismar JH, Bley CR, Pruschy M, Fuchs B, Studer G, Kuster N, Neufeld E, Caspar C, Bodis S
Hyperthermia Collaborative Research Network (HCRN) - Aargau, Solothurn and Zurich, SASRO, Davos, June 2013
Strahlenther Oncol 2013; 189(12),1085.

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Datta NR, Puric E,  A.Meister, Lomax N, Heuberger J, Marder D, Timm O, Goitein G, Lomax T, Geismar JH, Fuchs B, Studer G, Bode B, Bodis S
A multi-institutional phase I/II pilot study of proton radiotherapy with local hyperthermia in adult soft tissue sarcoma
SASRO, Davos, June 2013,Strahlenther Oncol 2013; 189(12),1085.

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Puric E, Datta NR, Lomax N, Timm O, Studer G, Fuchs B, Bode B, Bodis S
Differential effectiveness  radiotherapy versus radiotherapy and hyperthermia in a soft tissue sarcoma of the extremity: A case study
SASRO, Davos, June 2013, Strahlenther Oncol 2013; 189 (12),1085.