Forschung Radiologie

Unser Institut ist in diverse wissenschaftliche Projekte involviert, die zum Ziel haben, die radiologisch-diagnostischen Verfahren (z.B. CT, MRT) aussagekräftiger und sicherer für unsere Patientinnen und Patienten zu machen.

Hierfür bestehen verschiedene Kooperationen, unter anderem mit diversen Partnerkliniken des Kantonsspitals Aarau (z.B. Medizinische Universitätsklinik, Urologie), Universitätsspitälern (Universitätsspital Zürich) sowie Firmen. In den vergangenen Jahren kamen wissenschaftliche Kooperationen mit Firmen im In- und Ausland zum Thema künstlicher Intelligenz dazu.

An neuen wissenschaftlichen Kooperation mit internen und externen Partnern haben wir grosses Interesse und freuen uns auf Ihre Kontaktaufnahme.

Publikationen Radiologie

2016: Barth BK, Cornelius A, Nanz D, Eberli D, Donati OF: Comparison of image quality and patient discomfort in prostate MRI: pelvic phased array coil vs. endorectal coil. Abdominal Radiology 2016, 41(11):2218-2226. IF: 2.2

Burn F, Schirpenbach C, Bidlingmaier M, Reincke M, Vetter D, Weishaupt D, Brockmann JG, Muller MK, Weber M, Dahm F, Nocito A: Left-Sided Living Kidney Donation Leads to Transiently Reduced Adrenocortical Responsiveness. American Journal of Transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016.

Parakh A, Kortesniemi M, Schindera ST: CT Radiation Dose Management: A Comprehensive Optimization Process for Improving Patient Safety. Radiology 2016, 280(3):663-673. IF: 6.8

Zaehringer C, Euler A, Karwacki GM, Hohmann J, Pansini M, Szucs-Farkas Z, Schindera ST: Manual adjustment of tube voltage from 120 to 100 kVp during abdominal CT in patients with body weights </=75 kg: assessment of image quality and radiation dose in a prospective, randomised trial. Clinical Radiology 2016, 71(6):615 e611-616. IF: 2.2

Euler A, Parakh A, Falkowski AL, Manneck S, Dashti D, Krauss B, Szucs-Farkas Z, Schindera ST: Initial Results of a Single-Source Dual-Energy Computed Tomography Technique Using a Split-Filter: Assessment of Image Quality, Radiation Dose, and Accuracy of Dual-Energy Applications in an In Vitro and In Vivo Study. Investigative Radiology 2016, 51(8):491-498. IF: 4.9

Pansini M, Morsbach F, Schubert T, Hohmann J, Kovacs B, Szucs-Farkas Z, Schindera ST: Feasibility of Dose Optimization in a Second-Generation Dual-Source CT Scanner for a Manufacturer-Recommended Urolithiasis Protocol for Imaging Renal Stones. American Journal of Roentgenology 2016, 206(2):348-354. IF: 2.7

Korporaal JG, Benz MR, Schindera ST, Flohr TG, Schmidt B: Contrast Gradient-Based Blood Velocimetry With Computed Tomography: Theory, Simulations, and Proof of Principle in a Dynamic Flow Phantom. Investigative Radiology 2016, 51(1):41-49. IF: 4.9

Bosiers M1, Scheinert D2, Hendriks JM3, Wissgott C4, Peeters P5, Zeller T6, Brodmann M7, Staffa R8; Deloose K, de Vries JP, van den Heuvel DA, Krankenberg H, Kubicek L, Dorr A, Gissler HM, Schmidt A, Braunlich S, Ulrich M, Schuster J, Scheinert S, Bausback Y, Piorkowski M, Werner M, Verbist J, Maene L, Beelen R, Schwarzwälder U, Rastan A, Beschorner U, Sixt S, Pilger E, Eller P, Ricke J, Pech M, Ludtke C, Vojtisek B, Vlachovsky R: Results from the Tack Optimized Balloon Angioplasty (TOBA) study demonstrate the benefits of minimal metal implants for dissection repair after angioplasty. J Vasc Surg. 2016 Jul;64(1)
2017: Vascular 2017 Dec;25(6):563-575

Safety and effectiveness of the Phoenix Atherectomy System in lower extremity arteries: Early and midterm outcomes from the prospective multicenter EASE study.

Davis T1, Ramaiah V2, Niazi K3, Martin Gissler H4, Crabtree T5.

Radiology 2017, 284(3):725-736.

Detection of Clinically Significant Prostate Cancer: Short Dual-Pulse Sequence versus Standard Multiparametric MR Imaging-A Multireader Study.

Barth BK, De Visschere PJL, Cornelius A, Nicolau C, Vargas HA, Eberli D, Donati OF.

European Journal of Radiology 2017, 94:58-63.

Direct comparison of PI-RADS version 2 and version 1 regarding interreader agreement and diagnostic accuracy for the detection of clinically significant prostate cancer.

Becker AS, Cornelius A, Reiner CS, Stocker D, Ulbrich EJ, Barth BK, Mortezavi A, Eberli D, Donati OF.

European Journal of Radiology 2017, 93:65-69

Scan time adapted contrast agent injection protocols with low volume for low-tube voltage CT angiography: An in vitro study.

Benz MR, Szucs-Farkas Z, Froehlich JM, Stadelmann G, Bongartz G, Bouwman L, Schindera ST.

European Radiology 2017, 27(12):5260

Erratum to: Impact of model-based iterative reconstruction on low-contrast lesion detection and image quality in abdominal CT: a 12-reader-based comparative phantom study with filtered back projection at different tube voltages.

Euler A, Stieltjes B, Szucs-Farkas Z, Eichenberger R, Reisinger C, Hirschmann A, Zaehringer C, Kircher A, Streif M, Bucher S, Buergler D, D'Errico L, Kopp S, Wilhelm M, Schindera ST.

European Radiology 2017, 27(12):5252-5259

Impact of model-based iterative reconstruction on low-contrast lesion detection and image quality in abdominal CT: a 12-reader-based comparative phantom study with filtered back projection at different tube voltages.

Euler A, Stieltjes B, Szucs-Farkas Z, Eichenberger R, Reisinger C, Hirschmann A, Zaehringer C, Kircher A, Streif M, Bucher S, Buergler D, D'Errico L, Kopp S, Wilhelm M, Schindera ST.

JACC Cardiovascular Interventions 2017, 10(16):1694-1704

Self-Expanding Versus Balloon-Expandable Stents for Iliac Artery Occlusive Disease: The Randomized ICE Trial.

Krankenberg H, Zeller T, Ingwersen M, Schmalstieg J, Gissler HM, Nikol S, Baumgartner I, Diehm N, Nickling E, Muller-Hulsbeck S, Schmiedel R, Torsello G, Hochholzer W, Stelzner C, Brechtel K, Ito W, Kickuth R, Blessing E, Thieme M, Nakonieczny J, Nolte T, Gareis R, Boden H, Sixt S.

Abdominal Radiology. 2017 Dec;42(12):2898-2908

Cholangiocarcinoma and its mimickers in primary sclerosing cholangitis.

Lee JJ, Schindera ST, Jang HJ, Fung S, Kim TK.

AJR American Journal of Roentgenology 2017 Dec;209(6):1302-1307

Trans-Atlantic Comparison of CT Radiation Doses in the Era of Radiation Dose-Tracking Software.

Parakh A, Euler A, Szucs-Farkas Z, Schindera ST.

Abdominal Radiology 2017 Oct;42(10):2562-2570

Systematic radiation dose optimization of abdominal dual-energy CT on a second-generation dual-source CT scanner: assessment of the accuracy of iodine uptake measurement and image quality in an in vitro and in vivo investigations.

Schindera ST, Zaehringer C, D'Errico L, Schwartz F, Kekelidze M, Szucs-Farkas Z, Benz MR.

Radiation Oncology 2017, 12(1):183

"HEATPAC" - a phase II randomized study of concurrent thermochemoradiotherapy versus chemoradiotherapy alone in locally advanced pancreatic cancer.

Datta NR, Pestalozzi B, Clavien PA, Siebenhuner A, Puric E, Khan S, Mamot C, Riesterer O, Knuchel J, Reiner CS, Bodis S, members of the HTG.

AJNR Am J Neuroradiol. 2017 Dec 21

Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?

Tozakidou M, Reisinger C, Harder D, Lieb J, Szucs-Farkas Z, Müller-Gerbl M, Studler U, Schindera S, Hirschmann A.

Schweiz Med Forum 2017;17(11):269-271

Wenn das Pankreas im Thorax liegt.

Stephan Gerdes, Patrick Hollmann, Gaudenz Curti, Marco von Strauss und Torney.
2018: European Radiology 2018 Dec; 28:5044-5050

National survey on dose data analysis in computed tomography.

Heilmaier C, Treier R, Merkle EM, Alkadhi H, Weishaupt D, Schindera S.

Physica Medica: European Journal of Medical Physics 2018 Apr;48:111-118

Effects of various generations of iterative CT reconstruction algorithms on low-contrast detectability as a function of the effective abdominal diameter: A quantitative task-based phantom study.

Viry A, Aberle C, Racine D, Knebel JF, Schindera ST, Schmidt S, Becce F, Verdun FR.

European Radiology 2018 Aug;28:3405-3412

Comparison of image quality and radiation dose between split-filter dual-energy images and single-energy images in single-source abdominal CT.

Euler A, Obmann MM, Szucs-Farkas Z, Mileto A, Zaehringer C, Falkowski AL, Winkel DJ, Marin D, Stieltjes B, Krauss B, Schindera ST.

American Journal of Neuroradiology 2018 Feb;39:385-391

Systematic Radiation Dose Reduction in Cervical Spine CT of Human Cadaveric Specimens: How Low Can We Go?

Tozakidou M, Reisinger C, Harder D, Lieb J, Szucs-Farkas Z, Müller-Gerbl M, Studler U, Schindera S, Hirschmann A.

J Int Med Res. 2018 Dec 1-6

Primary urethral squamous cell carcinoma: a unique manifestation of a penile tumor.

Antwerpen I, Gstrein L, Moskovszky L, Gissler HM, Möltgen T, Kwiatkowski M, Wyler S, Walter M.
2019: Smith-Bindman R, Wang Y, Chu P, Chung R, Einstein AJ, Balcombe J, Cocker M, Das M, Delman BN, Flynn M, Gould R, Lee RK, Yellen-Nelson T, Schindera S, Seibert A, Starkey J, Suntharalingam S, Wetter A, Wildberger JE, Miglioretti DL.

International variation in radiation dose for computed tomography examinations: prospective cohort study.

BMJ. 2019 Jan 2;364:k4931.

Heilmaier C, Treier R, Merkle EM, Alkadhi H, Weishaupt D, Schindera S.

Correction to: National survey on dose data analysis in computed tomography.

Eur Radiol. 2019 Feb;29(2):1063

Aberle C, Ryckx N, Treier R, Schindera S.

Update of national diagnostic reference levels for adult CT in Switzerland and assessment of radiation dose reduction since 2010.

Eur Radiol. 2020 Mar;30(3):1690-1700

Tozakidou M, Apine I, Petersen KU, Weinrich JM, Schindera S, Jopp-van Well E, Püschel K, Herrmann J.

Comparison of different iterative CT reconstruction techniques and filtered back projection for assessment of the medial clavicular epiphysis in forensic age estimation.

Int J Legal Med. 2020 Jan;134(1):355-361.

Tozakidou M, Yang SR, Kovacs BK, Szucs-Farkas Z, Studler U, Schindera S, Hirschmann A.

Dose-optimized computed tomography of the cervical spine in patients with shoulder pull-down: Is image quality comparable with a standard dose protocol in an emergency setting?

Eur J Radiol. 2019 Nov;120:108655

Barth BK, Rupp NJ, Cornelius A, Nanz D, Grobholz R, Schmidtpeter M, Wild PJ, Eberli D, Donati OF.

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study.

Curr Urol. 2019 Mar 8;12(2):88-96

Gstrein L, Antwerpen I, Gissler HM, Kwiatkowski M, Wyler S, Walter M.

Renal pseudoaneuryms and pulmonary embolism: A unique manifestation of complications following blunt renal trauma.

Urol Case Rep. 2019 Jan 24;24:

Antwerpen I, Gstrein L, Moskovszky L, Gissler HM, Möltgen T, Kwiatkowski M, Wyler S, Walter M.

Primary urethral squamous cell carcinoma: a unique manifestation of a penile tumor.

J Int Med Res. 2019 Feb;47(2):999-1004.

Nickler M, Haubitz S, Méndez A, Gissler HM, Stierli P, Kieback A.

Phlegmasia cerulea dolens - an uncommon but alarming manifestation of deep vein thrombosis.

Vasa. 2020 Aug;49(5):422-426

Krankenberg H, Zeller T, Ingwersen M, Schmalstieg J, Gissler HM, Nikol S, Baumgartner I, Diehm N, Nickling E, Müller-Hülsbeck S, Schmiedel R, Torsello G, Hochholzer W, Stelzner C, Brechtel K, Ito W, Kickuth R, Blessing E, Thieme M, Nakonieczny J, Nolte T, Gareis R, Boden H, Sixt S.

Self-Expanding Versus Balloon-Expandable Stents for Iliac Artery Occlusive Disease: The Randomized ICE Trial.

JACC Cardiovasc Interv. 2017 Aug 28;10(16):1694-1704
2020: Loose RW, Vano E, Mildenberger P, Tsapaki V, Caramella D, Sjoberg J, Paulo G, Torresin A, Schindera S, Frija G, et al:

Radiation dose management systems-requirements and recommendations for users from the ESR EuroSafe Imaging initiative.

Eur Radiol 2020.

Nickler M, Haubitz S, Mendez A, Gissler HM, Stierli P, Kieback A:

Phlegmasia cerulea dolens - an uncommon but alarming manifestation of deep vein thrombosis.

Vasa 2020, 49:422-426.

Obmann MM, Gehweiler J, Schindera S, Janetzki J, Boll DT, Benz MR:

Clinical evaluation of a novel multibolus contrast agent injection protocol for thoraco-abdominal CT angiography: Assessment of homogeneity of arterial contrast enhancement.

Eur J Radiol 2020, 126:108957.

Tozakidou M, Apine I, Petersen KU, Weinrich JM, Schindera S, Jopp-van Well E, Püschel K, Herrmann J.

Comparison of different iterative CT reconstruction techniques and filtered back projection for assessment of the medial clavicular epiphysis in forensic age estimation.

Int J Legal Med. 2020 Jan;134(1):355-361.

Smith-Bindman R, Chu P, Wang Y, Chung R, Lopez-Solano N, Einstein AJ, Solberg L, Cervantes LF, Yellen-Nelson T, Boswell W, Delman BN, Duong PA, Goode AR, Kasraie N, Lee RK, Neill R, Pahwa A, Pike P, Roehm J, Schindera S, Starkey J, Suntharalingam S, Jeukens CRLPN, Miglioretti DL.

Comparison of the Effectiveness of Single-Component and Multicomponent Interventions for Reducing Radiation Doses in Patients Undergoing Computed Tomography: A Randomized Clinical Trial.

JAMA Intern Med. 2020 May 1;180(5):666-675

Aberle C, Ryckx N, Treier R, Schindera S.

Update of national diagnostic reference levels for adult CT in Switzerland and assessment of radiation dose reduction since 2010.

Eur Radiol. 2020 Mar;30(3):1690-1700
2021: Bos D, Yu S, Luong J, Chu P, Wang Y, Einstein AJ, Starkey J, Delman BN, Duong PT, Das M, Schindera S, Goode AR, MacLeod F, Wetter A, Neill R, Lee RK, Roehm J, Seibert JA, Cervantes LF, Kasraie N, Pike P, Pahwa A, Jeukens C, Smith-Bindman R:

Diagnostic reference levels and median doses for common clinical indications of CT: findings from an international registry.

European Radiology 2021.

Kienzler JC, Rey S, Wetzel O, Atassi H, Babler S, Burn F, Fandino J:

Incidence and clinical impact of vertebral endplate changes after limited lumbar microdiscectomy and implantation of a bone-anchored annular closure device.

BMC Surg 2021, 21(1):19.

Loose RW, Vano E, Mildenberger P, Tsapaki V, Caramella D, Sjoberg J, Paulo G, Torresin A, Schindera S, Frija G, Damilakis J, European Society of R:

Radiation dose management systems-requirements and recommendations for users from the ESR EuroSafe Imaging initiative.

European Radiology 2021, 31(4):2106-2114.

Tozakidou M, Meister RL, Well L, Petersen KU, Schindera S, Jopp-van Well E, Puschel K, Herrmann J:

CT of the medial clavicular epiphysis for forensic age estimation: hands up? International journal of legal medicine

2021, 135(4):1581-1587.

Viry A, Aberle C, Lima T, Treier R, Schindera S, Verdun FR, Racine D:

Assessment of task-based image quality for abdominal CT protocols linked with national diagnostic reference levels.

European Radiology 2021.

Wagener C, Schindera S, Kuntzen T, Grobholz R:

[Unexpected deposits in the upper gastrointestinal tract : When medical history matters].

Pathologe 2021, 42(2):235-240.