Neuroradiologie

"Hochspezialisierte Bildgebung des Nervensystems"

Forschung

Die Forschung besitzt in der Neuroradiologie des KSA einen hohen Stellenwert. Wir forschen sowohl mit internen wie externen Partnern, haben eigene Projekte und sind an nationalen wie internationalen Projekten beteiligt. Schwerpunkte sind der neurovaskuläre Bereich und MRI-basierte Arbeiten auf dem Gebiet der Neuroophthalmologie. Eigenständige Arbeit wird vollumfänglich unterstützt, wir sind aber auch in kompetente organisatorische Netzwerke eingegliedert. Um eine hohe Effizienz der Aktivitäten zu gewährleisten wurde von den Neuro-Disziplinen am KSA das Neuro Research Office gegründet. Es ist besetzt mit erfahrenen Studienkoordinatorinnen, die für eine einwandfreie und zielführende Durchführung der Forschungsprojekte sorgen und vor allem die jungen Forscher in den komplexen administrativen Aspekten der Projekte unterstützen.

Neuro Research Office

Das Neuro Research Office (NRO) unterstützt die forschungsintensiven Fachbereiche Neurologie, Neurochirurgie, Neuroradiologie und das Hirntumorzentrum des KSA bei der Entwicklung von Projekten im Bereich Forschung und Publikation. Es begleitet die Studienleiter von der Projekteinreichung, über die Planung, Organisation, Finanzierung, Auswertung bis zur Publikation. Des Weiteren organisiert und koordiniert das NRO für das gesamte KSA so genannte Good-Clinical-Practice-Kurse; welche Basiswissen zu den ethischen, gesetzlichen und operativen Rahmenbedingungen eines Forschungsprojektes vermitteln. Der Besuch eines solchen Kurses ist für Projektführer und das Einreichen eines Forschungsprojekts bei der Ethik-Kommission Voraussetzung.

Das Neuro Research Office arbeitet partnerschaftlich mit dem Forschungsrat zusammen und pflegt auch mit sämtlichen anderen Forschung betreibenden Stellen im KSA einen regen und engen Kontakt und Austausch.

Mehr zur Forschung am KSA

Kontakt

Anna Scrowther

Leiterin Neuro Research Office

Aktuelle Forschungsprojekte

Aktuelle Forschungsprojekte: Susceptibility changes in meningiomas increase the apparent diffusion coefficient in diffusion weighted MRI

Diffusion weighted magnetic resonance imaging (DWI) provides information of water diffusivity which is expressed by the apparent diffusion coefficient (ADC). It is not known which biological aspects of meningiomas are reflected by their behavior in ADC. Further it is not known whether intra-tumoral susceptibility changes alter ADC values. We analyzed whether intra-tumoral susceptibility weighted imaging positivity (SWIpos) influences ADC values in untreated meningiomas.

Responsible: Dr. phil. Jatta Berberat

Dynamic flexion-extension diffusion-tensor weighted imaging of the cervical spine: a feasibility study

In some cases of cervical spinal disease, MRI in flexion or extension may reveal T2-weighted signal changes which are not apparent in the neutral position. Both flexion-extension imaging and diffusion tensor imaging (DTI) have been reported to have a higher sensitivity than conventional T2-weighted imaging for the detection of myelopathy. A DTI-sequence performed in extension or flexion of the cervical spine may accentuate signal anomalies which are not apparent in the neutral position. Therefore DTI may serve as a tool to further improve the sensitivity for the detection of myelopathy. The aim of this study was to assess the feasibility and reproducibility of dynamic flexion-extension DTI in the cervical spinal cord in healthy volunteers.

Responsible: Dr. phil. Jatta Berberat

Dynamic flexion-extension diffusion-tensor weighted imaging of the cervical spine

MRI in flexion or extension reveals T2-weighted signal changes which are not apparent in the neutral position. Both flexion-extension imaging and diffusion tensor imaging (DTI) have been shown to have a higher sensitivity than conventional T2-weighted imaging for the detection of myelopathy. We have showed in our earlier project the feasibility and reproducibility of DTI in flexion-extension in the cervical spine (Schatlo et al, submitted). Therefore we want to explore the DTI in flexion-extension as a tool for improved sensitivity in cases of myelopathy compared to neutral imaging position.

Responsible: Dr. phil. Jatta Berberat

Changes in the Amygdala Produced by Viewing Strabismic Eyes

On our earlier project (Berberat et al. Opthalmology 2014) we showed that fMRI results confirm that strabismus influences organically not only the patient with nonparallel eyes but also observers.The aim of this study is to look for the response to strabismus images of kids in the limbic network (amygdala, hippocampus, parahippocampus) of mothers and to compare it with their reaction to viewing normal eyes for better understand the interpersonal dynamic for patients with strabismus on a demonstrable organic basis.

Responsible: Dr. phil. Jatta Berberat

Activation and functional connectivity in adults with Attention-Deficit Hyperactivity disorder (ADHD) during tasks of motor inhibition and cognitive switching

ADHD has been associated with fronto-striatal functional abnormalities during tasks of inhibitory control. In adults with ADHD, no studies have been investigated with combined fMRI, spectroscopy and neuropsychological evaluation to study the cognitive flexibility. The aim of the study is to investigate the response of healthy test persons compared to adults with or without medication against ADHD.

Responsible: Dr. phil. Jatta Berberat

MEMBO- Changes in Perfusion, Diffusivity and Susceptibility in Meningioma after Embolization

The aim of this study is to quantify morphological correlates of the physiological changes occurring in meningiomas following embolization with Embozene® microspheres in standard patient care. With regard to the standard time frame of surgery we will therefore investigate patients immediately (appr. 6 hours) and delayed (appr. 48 hours) after embolization for changes in blood volume, diffusivity, micro bleeds and peri-tumoral edema with a MRI examination at each of these time points.
Primary outcome measures
Tumor tissue transformation as assessed with the following MRI parameters after embolization: changes in blood volume, diffusivity, susceptibility (micro-bleeds)
Secondary outcome measures
Edema in brain regions adjacent to the meningioma

Responsible: Dr. phil. J. Berberat

Diffusion MRI: CSF Flow in optic nerve

The mechanism by which cerebral spinal fluid (CSF) is propelled on its circulatory route is not fully understood. The optic nerve can become involved in CNS disorders characterized by elevated intra cranial pressure, intracranial masses, and inflammatory and infectious disease. Therefore, a non-invasive method to observe the CSF flow surrounding the optic nerve is urgently needed. Until now, an invasive CT-cisternography with contrast agent has been used.
We have developed a technique that allows us to observe the CSF flow in optic nerve using non-invasive MRI.

Responsible: Dr. phil. Jatta Berberat

The question about best initial medical therapy in patients with elective carotid artery stenting for acute symptomatic carotid stenosis with intraluminal carotid thrombus

Symptomatische Karotissstenosen mit distal gelegenem intraluminalen Thrombus der Arteria Karotis interna sind selten, jedoch verhängnisvoll, da sie mit einer hohen Komplikationsrate einhergehen. In diversen Studien wurde ein erfolgreiches zweizeitiges Vorgehen (initiale medikamentöse Behandlung mit nachfolgendem elektivem Stenting oder elektiver Endarterektomie) beschrieben. Bei der pharmakologischen Behandlung wurde jedoch eine grosse Variation an Substanzen eingesetzt und die definitiv versorgende Therapie zu unterschiedlichen Zeitpunkten durchgeführt. Vorteile der Art
und Dauer der primären medikamentösen Therapie wurden jedoch bis dato nicht analysiert. Das Ziel unserer Studie ist die Analyse der initialen medikamentösen Behandlung, sowie des Outcomes bei dieser zweizeitigen Therapie. Es sollen dabei die Vor- und Nachteile der eingesetzten Substanzklassen sowie deren Therapiedauer untersucht werden. Wir untersuchen dafür retrospektiv 4 aufeinanderfolgende Patienten mit einer Karotisstenose mit nachgeschaltetem intraluminalen Thrombus in derselben Arterie, bei welchen an unserer Klinik zwischen 2008 und 2014 initial eine medikamentöse Therapie zur Thrombusauflösung und anschliessend in einem zweiten Schritt eine definitive Stenosebehandlung mittels Stent-Implantation durchgeführt.

Responsible: Prof. Dr. med. L. Remonda

Publikationen

2015: Schwyzer L, Berberat J, Remonda L, Roelcke U
Susceptibility changes in meningiomas influence the apparent diffusion coefficient in diffusion-weighted MRI
J Neuroradiol. 2015 Sep 22. pii: S0150-9861(15)00111-X. doi: 10.1016/j.neurad.2015.06.002. [Epub ahead of print]

Boye D, Springer O, Wassmer F, Scheidegger S, Remonda L, Berberat J
Effects of contour propagation and background corrections in different MRI flow software packages
Acta Radiol Open. 2015 Jun 19;4(6):2058460115589124. doi: 10.1177/2058460115589124. eCollection 2015 Jun

Hlavica M, Ineichen BV, Fathi AR, Remonda L, Diepers M
Parasagittal Dural Arteriovenous Fistula Treated With Embozene Microspheres
J Endovasc Ther. 2015 Sep 3. pii: 1526602815604464. [Epub ahead of print]

Kahles T, Garcia-Esperon C, Zeller S, Hlavica M, Añon J, Diepers M, Nedeltchev K, Remonda L
Mechanical Thrombectomy Using the New ERIC Retrieval Device Is Feasible, Efficient, and Safe in Acute Ischemic Stroke: A Swiss Stroke Center Experience
AJNR Am J Neuroradiol. 2015 Aug 20. [Epub ahead of print]

Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW, Devlin TG, Lopes DK, Reddy VK, du Mesnil de Rochemont R, Singer OC, Jahan R; SWIFT PRIME Investigators
Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke
N Engl J Med. 2015 Jun 11;372(24):2285-95. doi: 10.1056/NEJMoa1415061. Epub 2015 Apr 17

Schatlo B, Fandino J, Smoll NR, Wetzel O, Remonda L, Marbacher S, Perrig W, Landolt H, Fathi AR
Outcomes after combined use of intraoperative MRI and 5-aminolevulinic acid in high-grade glioma surgery
Neuro Oncol. 2015 Apr 8. pii: nov049. [Epub ahead of print]

Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Devlin TG, Lopes DK, Reddy V, du Mesnil de Rochemont R, Jahan R; SWIFT PRIME Investigators
Solitaire™ with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire revascularization device with IV tPA with IV tPA alone in acute ischemic stroke
Int J Stroke. 2015 Apr;10(3):439-48. doi: 10.1111/ijs.12459

Coluccia D, Fandino J, Schwyzer L, O'Gorman R, Remonda L, Anon J, Martin E, Werner B
First noninvasive thermal ablation of a brain tumor with MR-guided focused ultrasound
J Ther Ultrasound. 2014 Oct 16;2:17. doi: 10.1186/2050-5736-2-17. eCollection 2014

Hlavica M, Diepers M, Garcia-Esperon C, Ineichen BV, Nedeltchev K, Kahles T, Remonda L
Pharmacological recanalization therapy in acute ischemic stroke - evolution, current state and perspectives of intravenous and intra-arterial thrombolysis
J Neuroradiol. 2015 Feb;42(1):30-46. doi: 10.1016/j.neurad.2014.11.004. Epub 2015 Jan 31. Review

Soleman J, Schatlo B, Dan-Ura H, Remonda L, Fandino J, Fathi AR
Craniotomy without flap replacement for ruptured intracranial aneurysms to reduce ischemic brain injury: a preliminary safety and feasibility analysis
Acta Neurochir Suppl. 2015;120:217-22. doi: 10.1007/978-3-319-04981-6_37

Danura H, Schatlo B, Marbacher S, Kerkeni H, Diepers M, Remonda L, Fathi AR, Fandino JAcute angiographic vasospasm and the incidence of delayed cerebral vasospasm: preliminary results
Acta Neurochir Suppl. 2015;120:187-90. doi: 10.1007/978-3-319-04981-6_32

Kerkeni H, Schatlo B, Dan-Ura H, Remonda L, Muroi C, Diepers M, Fandino J, Fathi ARProximal arterial diameters on CT angiography and digital subtraction angiography correlate both at admission and in the vasospasm period after aneurysmal subarachnoid hemorrhage
Acta Neurochir Suppl. 2015;120:171-5. doi: 10.1007/978-3-319-04981-6_29

Nevzati E, Marbacher S, Soleman J, Perrig WN, Diepers M, Khamis A, Fandino J
Accuracy of pedicle screw placement in the thoracic and lumbosacral spine using a conventional intraoperative fluoroscopy-guided technique: a national neurosurgical education and training center analysis of 1236 consecutive screws
World Neurosurg. 2014 Nov;82(5):866-71.e1-2. doi: 10.1016/j.wneu.2014.06.023. Epub 2014 Jun 17

Marbacher S, Klinger E, Schwyzer L, Fischer I, Nevzati E, Diepers M, Roelcke U, Fathi AR, Coluccia D, Fandino J
Use of fluorescence to guide resection or biopsy of primary brain tumors and brain metastases
Neurosurg Focus. 2014 Feb;36(2):E10. doi: 10.3171/2013.12.FOCUS13464

Coluccia D, Anon J, Rossi F, Marbacher S, Fandino J, Berkmann S
Intraoperative Fluoroscopy for Ventriculoperitoneal Shunt Placement
World Neurosurg. 2015 Sep 4. pii: S1878-8750(15)01088-8. doi: 10.1016/j.wneu.2015.08.072. [Epub ahead of print]

Ehrmann C, Rosskopf AB, Pfirrmann CW, Sutter R
Beyond the alpha angle: Alternative measurements for quantifying cam-type deformities in femoroacetabular impingement
J Magn Reson Imaging. 2015 Oct;42(4):1024-31. doi: 10.1002/jmri.24861. Epub 2015 Feb 2
2014: Berberat J, McNamara J, Remonda L, Bodis S, Rogers S
Diffusion tensor imaging for target volume definition in glioblastoma multiforme
Strahlenther Onkol. 2014 Oct;190(10):939-43. doi: 10.1007/s00066-014-0676-3. Epub 2014 May 14

Berberat J, Grobholz R, Boxheimer L, Rogers S, Remonda L, Roelcke U
Differentiation between calcification and hemorrhage in brain tumors using susceptibility-weighted imaging: a pilot study
AJR Am J Roentgenol. 2014 Apr;202(4):847-50. doi: 10.2214/AJR.13.10745

Erhardt S, Marbacher S, Neuschmelting V, Coluccia D, Remonda L, Fandino J
Comparison between routine cylindrical cerebral aneurysm volume approximation and three-dimensional volume measurements in experimental aneurysms
Neurol Res. 2014 Aug;36(8):739-45. doi: 10.1179/1743132813Y.0000000316. Epub 2014 Jan 20

Rahm V, Boxheimer L, Bruehlmeier M, Berberat J, Nitzsche EU, Remonda L, Roelcke U
Focal changes in diffusivity on apparent diffusion coefficient MR imaging and amino acid uptake on PET do not colocalize in nonenhancing low-grade gliomas
J Nucl Med. 2014 Apr;55(4):546-50. doi: 10.2967/jnumed.113.130732. Epub 2014 Feb 24

Berberat J, Killer HE, Remonda L
What is BOLD?
J Pediatr Ophthalmol Strabismus. 2014 Jan-Feb;51(1):11. doi: 10.3928/01913913-20140106-03. No abstract available

Nevzati E, Marbacher S, Soleman J, Perrig WN, Diepers M, Khamis A, Fandino JAccuracy of pedicle screw placement in the thoracic and lumbosacral spine using a conventional intraoperative fluoroscopy-guided technique: a national neurosurgical education and training center analysis of 1236 consecutive screws

World Neurosurg. 2014 Nov;82(5):866-71.e1-2. doi: 10.1016/j.wneu.2014.06.023. Epub 2014 Jun 17

Marbacher S, Klinger E, Schwyzer L, Fischer I, Nevzati E, Diepers M, Roelcke U, Fathi AR, Coluccia D, Fandino J
Use of fluorescence to guide resection or biopsy of primary brain tumors and brain metastases
Neurosurg Focus. 2014 Feb;36(2):E10. doi: 10.3171/2013.12.FOCUS13464

Coluccia D, Fandino J, Schwyzer L, O'Gorman R, Remonda L, Anon J, Martin E, Werner B
First noninvasive thermal ablation of a brain tumor with MR-guided focused ultrasound
J Ther Ultrasound. 2014 Oct 16;2:17. doi: 10.1186/2050-5736-2-17. eCollection 2014

Ehrmann C, Maier M, Mengiardi B, Pfirrmann CW, Sutter R
Calcaneal attachment of the plantar fascia: MR findings in asymptomatic volunteers
Radiology. 2014 Sep;272(3):807-14. doi: 10.1148/radiol.14131410. Epub 2014 May 7

Bouaicha S, Ehrmann C, Slankamenac K, Regan WD, Moor BK
Comparison of the critical shoulder angle in radiographs and computed tomography
Skeletal Radiol. 2014 Aug;43(8):1053-6. doi: 10.1007/s00256-014-1888-4. Epub 2014 Apr 18
2013: Roelcke U, Boxheimer L, Fathi AR, Schwyzer L, Ortega M, Berberat J, Remonda L
Cortical hemosiderin is associated with seizures in patients with newly diagnosed malignant brain tumors
J Neurooncol. 2013 Dec;115(3):463-8. doi: 10.1007/s11060-013-1247-7. Epub 2013 Sep 18

Berberat J, Jaggi GP, Wang FM, Remonda L, Killer HE
Changes in the amygdala produced by viewing strabismic eyes
Ophthalmology. 2013 Oct;120(10):2125-9. doi: 10.1016/j.ophtha.2013.03.034. Epub 2013 May 21

Berberat J, Eberle B, Rogers S, Boxheimer L, Lutters G, Merlo A, Bodis S, Remonda L
Anisotropic phantom measurements for quality assured use of diffusion tensor imaging in clinical practice
Acta Radiol. 2013 Jun;54(5):576-80. doi: 10.1177/0284185113476018. Epub 2013 Apr 30

Mono ML, Karameshev A, Slotboom J, Remonda L, Galimanis A, Jung S, Findling O, De Marchis GM, Luedi R, Kiefer C, Stuker C, Mattle HP, Schroth G, Arnold M, Nedeltchev K, El-Koussy M
Plaque characteristics of asymptomatic carotid stenosis and risk of stroke
Cerebrovasc Dis. 2012;34(5-6):343-50. doi: 10.1159/000343227. Epub 2012 Nov 14

Fandino J, Taussky P, Marbacher S, Muroi C, Diepers M, Fathi AR, Remonda L
The concept of a hybrid operating room: applications in cerebrovascular surgery
Acta Neurochir Suppl. 2013;115:113-7. doi: 10.1007/978-3-7091-1192-5_24

Schubert GA, Diepers M, Hegewald AA, Seiz M, Thomé C
Routine postoperative imaging early after lumbar decompression surgery: a prospective evaluation
Spine (Phila Pa 1976). 2013 Sep 15;38(20):E1263-8. doi: 10.1097/BRS.0b013e31829fc6a6

Lopez-Benitez R, Rusch O, Heverhagen J, Levent K, Hanno H, Geiser C, Kettenbach J
The "embowire" technique: concept and description of a novel embolization technique for narrow vessels
Cardiovasc Intervent Radiol. 2013 Oct;36(5):1393-8. doi: 10.1007/s00270-013-0608-0. Epub 2013 Apr 12

López-Benítez R, Hallscheidt P, Kratochwil C, Ernst C, Kara L, Rusch O, Vock P, Kettenbach J
Protective embolization of the gastroduodenal artery with a one-HydroCoil technique in radioembolization procedures
Cardiovasc Intervent Radiol. 2013 Feb;36(1):105-10. doi: 10.1007/s00270-012-0361-9. Epub 2012 Mar 14
2012: Marbacher S, Tastan I, Neuschmelting V, Erhardt S, Coluccia D, Sherif C, Remonda L, Fandino J
Long-term patency of complex bilobular, bisaccular, and broad-neck aneurysms in the rabbit microsurgical venous pouch bifurcation model
Neurol Res. 2012 Jul;34(6):538-46. doi: 10.1179/1743132812Y.0000000040. Epub 2012 May 30

Berkmann S, Fandino J, Müller B, Remonda L, Landolt H
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma
Acta Neurochir (Wien). 2012 Apr;154(4):639-47. doi: 10.1007/s00701-012-1285-5

Sherif C, Marbacher S, Fandino J, Erhardt S, Neuschmelting V, Killer M, Mach G, Remonda L
3D computerized occlusion rating of embolized experimental aneurysms using noninvasive 1.5T MR imaging
AJNR Am J Neuroradiol. 2012 Apr;33(4):661-6. doi: 10.3174/ajnr.A2843. Epub 2011 Dec 22

Nedeltchev K, Remonda L, Schroth G
Letter by Nedeltchev et al regarding article, "Short-term outcomes after symptomatic internal carotid artery occlusion"
Stroke. 2012 Jan;43(1):e8: author reply e9. doi: 10.1161/STROKEAHA.111.638452. Epub 2011 Dec 1. No abstract available

Killer HE, Miller NR, Flammer J, Meyer P, Weinreb RN, Remonda L, Jaggi GP
Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma
Br J Ophthalmol. 2012 Apr;96(4):544-8. doi: 10.1136/bjophthalmol-2011-300663. Epub 2011 Nov 24

Woitzik J, Dreier JP, Hecht N, Fiss I, Sandow N, Major S, Winkler M, Dahlem YA, Manville J, Diepers M, Muench E, Kasuya H, Schmiedek P, Vajkoczy P; COSBID study group
Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage
J Cereb Blood Flow Metab. 2012 Feb;32(2):203-12. doi: 10.1038/jcbfm.2011.169. Epub 2011 Dec 7

Schindera ST, Hareter LF, Raible S, Torrente JC, Rusch O, Rosskopf AB, Marin D, Vock P, Szucs-Farkas Z
Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging
Invest Radiol. 2012 Mar;47(3):197-201. doi: 10.1097/RLI.0b013e3182361dbe
Publikationen 2011 und älter: siehe PubMed